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Neuroprotective role of curcumin from Curcuma longa on ethanol‐induced brain damage
Author(s) -
Rajakrishnan V.,
Viswanathan P.,
Rajasekharan K. N.,
Me Venugopal P.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199911)13:7<571::aid-ptr494>3.0.co;2-7
Subject(s) - curcumin , neuroprotection , pharmacognosy , ethanol , pharmacology , traditional medicine , chemistry , medicine , in vitro , biochemistry , biological activity
In the present study, curcumin from Curcuma longa was screened for neuroprotective activity using ethanol as a model of brain injury. Oral administration of curcumin to rats caused a significant reversal in lipid peroxidation, brain lipids and produced enhancement of glutathione, a non‐enzymic antioxidant in ethanol intoxicated rats, revealing that the antioxidative and hypolipidaemic action of curcumin isresponsible for its protective role against ethanol induced brain injury. Copyright © 1999 John Wiley & Sons, Ltd.