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Triterpene antioxidants from Ganoderma lucidum
Author(s) -
Zhu Min,
Chang Qi,
Wong Leone K.,
Chong Finny S.,
Li Ronald C.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<529::aid-ptr481>3.0.co;2-x
Subject(s) - triterpene , terpene , chemistry , ascorbic acid , pyrogallol , polysaccharide , antioxidant , pharmacognosy , chromatography , traditional medicine , food science , biological activity , biochemistry , in vitro , medicine , alternative medicine , pathology
Ganoderma lucidum was studied for its antioxidative activity by bioassay guided isolation in conjunction with in vitro tests. The powdered crude drug was treated with boiling water and the aqueous extract (Ex1) was further separated to obtain terpene and polysaccharide fractions. The two fractions and Ex1 were screened for their antioxidative effect against pyrogallol induced erythrocyte membrane oxidation and Fe (II)‐ascorbic acid induced lipid peroxidation. All tested samples showed antioxidative activities in a dose dependent manner and the terpene fraction was found to possess the highest effect compared with the others. Chemical isolation of the terpene fraction resulted in the detection of ganoderic acids A, B, C and D, lucidenic acid B and ganodermanontriol as major ingredients. Copyright © 1999 John Wiley & Sons, Ltd.