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Effect of extract prepared from the roots of Paeonia lactiflora on endothelium‐dependent relaxation and antioxidant enzyme activity in rats administered high‐fat diet
Author(s) -
Goto Hirozo,
Shimada Yutaka,
Tanaka Nobumitsu,
Tanigawa Kiyoaki,
Itoh Takashi,
Terasawa Katsutoshi
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<526::aid-ptr487>3.0.co;2-o
Subject(s) - paeonia lactiflora , superoxide dismutase , antioxidant , superoxide , endothelium , endothelial dysfunction , pharmacognosy , pharmacology , endocrinology , medicine , enzyme , chemistry , biochemistry , traditional medicine , biological activity , in vitro , pathology , alternative medicine
This study examined the effect of Paeoniae Radix (PR) on endothelial function and the activity of superoxide dismutase (SOD) of erythrocytes in rats administered a high‐fat diet. Administration of the extract of PR increased the endothelium‐dependent relaxation and the activities of SOD compared with high the cholesterol diet group significantly. Hypercholesterolaemia induced an increase of endothelial superoxide anion and endothelial dysfunction. Paeoniae Radix is suggested to have a protective effect on endothelial cells and their function. Copyright © 1999 John Wiley & Sons, Ltd.