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Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L.
Author(s) -
Oku Hisae,
Ishiguro Kyoko
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<521::aid-ptr535>3.0.co;2-a
Subject(s) - antagonist , platelet activating factor , pharmacology , chemistry , traditional medicine , stereochemistry , medicine , biochemistry , receptor
A blood pressure monitoring system was developed for studying antagonist effects against platelet activating factor (PAF), a chemical mediator of anaphylactic hypotension. Using this system, we were able to determine the inhibitory effects of a 35% ethanol extract (IB) from the petals of Impatiens balsamina L. against PAF‐induced hypotension and the active principal compounds from IB. One mechanism of the antianaphylactic effects of IB was characterized as PAF‐antagonist effects. Copyright © 1999 John Wiley & Sons, Ltd.