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Modulatory effects of Ixora coccinea flower on cyclophosphamide‐induced toxicity in mice
Author(s) -
Latha P. G.,
Panikkar K. R.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<517::aid-ptr524>3.0.co;2-y
Subject(s) - toxicity , alkaline phosphatase , cyclophosphamide , pharmacology , phytochemical , chemoprotective , transaminase , ursolic acid , chemistry , biology , toxicology , traditional medicine , biochemistry , medicine , botany , enzyme , chemotherapy , organic chemistry
The active fraction of Ixora coccinea flowers showed chemoprotective effects on cyclophosphamide ‐ induced toxicity by increasing the life span of treated mice, preventing body weight loss and maintaining near normal leucocyte and haemoglobin levels compared with cyclophosphamide treated controls. Decreased serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (SAKP) levels in the Ixora coccinea treated groups indicated protection against hepatic toxicity. The active fraction was identified by phytochemical methods as the triterpenoid, ursolic acid. Copyright © 1999 John Wiley & Sons, Ltd.