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Protection against cytotoxic effects of arsenic by dietary supplementation with crude extract of Emblica officinalis fruit
Author(s) -
Biswas Sonali,
Talukder Geeta,
Sharma Archana
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<513::aid-ptr525>3.0.co;2-6
Subject(s) - sodium arsenite , arsenic , traditional medicine , oral administration , pharmacology , toxicity , biology , chemistry , toxicology , medicine , organic chemistry
Dietary administration of a crude aqueous extract of Emblica officinalis Gaertn. fruit reduced significantly the cytotoxic effects of sodium arsenite administered orally. The crude extract (685 mg/kg bw) was given daily by gavaging to age and sex matched laboratory bread Swiss albino mice for 7 and 14 days, followed by a single dose of sodium arsenite (2.5 mg/kg bw = 1/10 of LD 50 ). The animals were killed after 24 h and chromosome preparations made following a schedule of colchicine–fixative–air drying–Giemsa. The endpoints screened were chromosomal aberrations and damaged cells. The crude extract reduced arsenic damage bringing the cells almost to the normal level. Copyright © 1999 John Wiley & Sons, Ltd.