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The antihyperglycaemic blend effect of traditional Chinese medicine Byakko‐ka‐ninjin‐to on alloxan and diabetic KK‐CA y mice
Author(s) -
Kimura Ikuko,
Nakashima Noboru,
Sugihara Yoshitaka,
Fujun Chen,
Kimura Masayasu
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<484::aid-ptr485>3.0.co;2-x
Subject(s) - glycyrrhizin , ginseng , alloxan , traditional medicine , glycyrrhiza , glibenclamide , tolbutamide , medicine , pharmacology , diabetes mellitus , endocrinology , alternative medicine , pathology
The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko‐ka‐ninjin‐to (BN; consisted of five crude drugs, ginseng, anemarrhena,licorice, gypsum and rice) was investigated using genetically obese diabetic KK‐CA y mice and alloxan‐diabetic mice. The water extract of ginseng, anemarrhena, licorice and gypsum when individually tested markedly lowered blood glucose levels in diabetic animals. Antihyperglycaemic effects of ginseng–anemarrhena and ginseng–licorice combinations were decreased compared with the respective individualeffects. Such decreased effects were partially reversed by adding gypsum or by substituting CaCl 2 for gypsum. The combination of D‐O‐ANa and glycyrrhizin, respectively the main constituents from ginseng and licorice, also demonstrated a decreased effect compared with the respective individual effects. The CaCl 2 at 0.5 mg/kg (i.p.) was sufficient to partially reverse these effects. These results indicate that antihyperglycaemic effects of BN depend on four crude drugs and Ca 2+ in the blend. Copyright © 1999 John Wiley & Sons, Ltd.