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Triptolide is more effective in preventing T cell proliferation and interferon‐gamma production than is FK506
Author(s) -
Chan Marcia A.,
Kohlmeier Jacob E.,
Branden Michael,
Jung Michel,
Benedict Stephen H.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199909)13:6<464::aid-ptr483>3.0.co;2-4
Subject(s) - triptolide , interferon gamma , gamma interferon , interferon γ , medicine , interferon , cell growth , immunology , traditional medicine , pharmacology , biology , cytokine , biochemistry , apoptosis
The Chinese traditional herb Tripterygium wilfordii Hook. F (TWHF) has been reported to be effective in the treatment of a variety of autoimmune disorders. The major active component of this herb is triptolide and most of the efficacy of this herb immunosuppression is attributed to triptolide. FK506 is also a potent immunosuppressive agent and is currently being used clinically. The present studies compare the effectiveness of triptolide and FK506 to suppress certain human T cell functions. Specifically human T cell proliferation, IL‐2 and IFNγ were compared. The results show that, overall, triptolide is more effective at inhibiting T cell proliferation and IFNγ production than FK506 and the two compounds inhibit IL‐2 production in an equivalent manner. Copyright © 1999 John Wiley & Sons, Ltd.