Premium
Effects of ethanol extract of Moringa stenopetala leaves on guinea‐pig and mouse smooth muscle
Author(s) -
Mekonnen Yalemtsehay
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199908/09)13:5<442::aid-ptr476>3.0.co;2-7
Subject(s) - antispasmodic , moringa , ileum , guinea pig , duodenum , traditional medicine , uterus , acetylcholine , ethanol , stomach , biology , pharmacognosy , smooth muscle , biological activity , pharmacology , endocrinology , medicine , biochemistry , in vitro
The fresh leaf ethanol (LE) extract of Moringa stenopetala was tested in guinea‐pig ileum and mouse duodenum and in uterus strips. There were significant dose and time dependent reductions of the acetylcholine (AC) response with initial stimulatory effects in both the guinea‐pig ileum and the mouse duodenum preparations. Spontaneous rhythmic contractions were greatly reduced, suggesting an antispasmodic property of the crude LE extract. The LE extract showed some oxytocic activity on uterus strips of guinea‐pigs and mice. The results are indicative of the traditional use of the leaves of Moringa stenopetala for stomach pain and to expel retained placentae by women. Copyright © 1999 John Wiley & Sons, Ltd.