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Some pharmacological and toxicological studies on Balanites aegyptiaca bark
Author(s) -
Mohamed A. H.,
Eltahir K. E. H.,
Ali M. B.,
Galal M.,
Ayeed I. A.,
Adam S. I.,
Hamid O. A.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199908/09)13:5<439::aid-ptr460>3.0.co;2-6
Subject(s) - bilirubin , medicine , toxicity , pharmacology , traditional medicine , stomach , aqueous extract , oral administration
The aqueous extract of Balanites aegyptiaca bark, which is used in Sudanese folk medicine in the treatment of jaundice, was without effect when studied on rabbit intestine, rabbit aortic strip, rat stomach strip, rat uterus and rat phrenic nerve–diaphragm in a dose up to 10 mg/mL gut bath. In a larger dose (25 mg) the extract decreased significantly the contractility and the rate of the isolated perfused rabbit heart. Administration of the aqueous extract to biliary duct‐ligated rats, showed a dose‐dependent significant decrease in serum bilirubin level. The chronic and subchronic toxicity investigations indicate the safety of the aqueous extract at a dose level which showed a significant decrease in serum bilirubin level in experimental obstructive jaundice in rats. Copyright © 1999 John Wiley & Sons, Ltd.