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Central nervous system depressant effect of Hoslundia opposita Vahl
Author(s) -
Olajide O. A.,
Awe S. O.,
Makinde J. M.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199908/09)13:5<425::aid-ptr466>3.0.co;2-1
Subject(s) - central nervous system , depressant , pharmacognosy , convulsion , traditional medicine , pharmacology , anticonvulsant , medicine , phytotherapy , biology , biological activity , epilepsy , in vitro , neuroscience , pathology , biochemistry , alternative medicine
The chloroform extract of the dried root of Hoslundia opposita has been evaluated for effects on the central nervous system (CNS). The extract significantly potentiated the phenobarbitone sleeping time in mice and produced a 60% protection against leptazol‐induced convulsion. Neuropharmacological screening revealed CNS depression. Copyright © 1999 John Wiley & Sons, Ltd.