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Effects of Daniellia <?tcaps=0>oliveri stem bark and leaf extracts on rat skeletal muscle
Author(s) -
Onwukaeme N. D.,
Lot T. Y.,
Udoh F. V.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199908/09)13:5<419::aid-ptr470>3.0.co;2-7
Subject(s) - bark (sound) , glycoside , skeletal muscle , saponin , chemistry , traditional medicine , pharmacognosy , biology , medicine , biological activity , biochemistry , anatomy , stereochemistry , in vitro , ecology , alternative medicine , pathology
The stem bark and leaves of Daniellia oliveri were screened phytochemically and the effects of their respective methanol extracts on the skeletal muscle of rats were investigated using the isolated phrenic nerve hemidiaphragm muscle preparation. Both were found to contain tannins, cardiac and saponin glycosides. In addition, the bark, but not leaves, contained cyanogenetic glycosides. The methanol extracts were found to possess neuromuscular blocking properties. The leaf extract appeared to act primarily by inhibiting the influx of extracellular Ca 2+ principally by inhibiting K + channels. The inhibitory action of the bark extract appeared to be mediated by interference with transmitter release and an action on multiple sites. Copyright © 1999 John Wiley & Sons, Ltd.