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Dominant lethal study of α‐asarone in male and female mice after sub‐chronic treatment
Author(s) -
Chamorro Germán,
Salazar María,
Tamariz Joaquín,
Díaz Francisco,
Labarrios Fernando
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199906)13:4<308::aid-ptr449>3.0.co;2-x
Subject(s) - histology , sperm , mating , biology , testosterone (patch) , spermatogenesis , ratón , dominant lethal , adult male , epididymis , physiology , reproduction , testicle , andrology , medicine , endocrinology , genetics
Dominant lethal studies were conducted in male and female mice with α‐asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub‐chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. α‐Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed toreveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology. Copyright © 1999 John Wiley & Sons, Ltd.