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Effects of Fructus schizandrae on cycloheximide‐induced amnesia in rats
Author(s) -
Hsieh MingTsuen,
Tsai MengLin,
Peng WenHuang,
Wu ChiRei
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<256::aid-ptr435>3.0.co;2-h
Subject(s) - cycloheximide , amnesia , fraction (chemistry) , chemistry , pharmacology , medicine , traditional medicine , chromatography , biochemistry , protein biosynthesis , psychiatry
The effects of Fructus Schisandrae ( Schizandra Chinensis , (FS) on cycloheximide (CXM)‐induced am‐nesia by using a passive avoidance task were studied in rats. FS at 0.25 and 0.75 g/kg administered for 1 week significantly prolonged the CXM‐shortened step‐through latency (STL). Of the fractions ( n ‐hexane, chloroform and water), only the water fraction at 25 mg/kg administered for 1 week prolonged the CXM‐shortened STL. These results suggest that the water fraction is the main active fraction of FS. Copyright © 1999 John Wiley & Sons, Ltd.