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Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin
Author(s) -
Pennacchio M.,
Syah Y. M.,
Alexander E.,
Ghisalberti E. L.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<254::aid-ptr430>3.0.co;2-1
Subject(s) - verbascoside , prostacyclin , mechanism of action , perfusion , pharmacology , medicine , endocrinology , chemistry , biochemistry , in vitro , stereochemistry , glycoside
The mechanism of the positive cardioactive effects induced by verbascoside in the Lagendorff rat heart has been investigated. Isolated rat hearts treated with α‐ or β‐ adrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside. A significant increase in prostacyclin levels (142%) observed following the administration of verbascoside suggests that prostacyclin stimulates formation of cAMP which induces the cardioactivity associated with verbascoside. Copyright © 1999 John Wiley & Sons, Ltd.