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Inhibitory effects of Ougi‐keishi‐gomotsu‐to, a traditional herbal medicine, on lipid peroxidation and protein oxidative modification of mouse brain homogenate induced by copper
Author(s) -
Toda Shizuo,
Yase YYoshiro
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<251::aid-ptr428>3.0.co;2-o
Subject(s) - lipid peroxidation , pharmacognosy , traditional medicine , folk medicine , phytotherapy , medicine , pharmacology , oxidative phosphorylation , chemistry , oxidative stress , biochemistry , biological activity , in vitro , alternative medicine , pathology
Ougi‐Keishi‐gomotsu‐to a traditional herbal medicine, is used clinically for patients with abnormal sensations and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification of brain homogenate induced by copper. Its effect was stronger than those of mannitol and α‐tocopherol as free radical scavenger and antioxidant. These results demonstrated that Ougi‐keishi‐gomotsu‐to has antioxidative effects on neuron injury derived from oxidative stress induced by metal. Copyright © 1999 John Wiley & Sons, Ltd.