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Effect of Choto‐san, a Kampo medicine, on impairment of passive avoidance performance in mice
Author(s) -
Yuzurihara Mitsutoshi,
Goto Kazuhiro,
Sugimoto Akira,
Ishige Atsushi,
Komatsu Yasuhiro,
Shimada Yutaka,
Terasawa Katsutoshi
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<233::aid-ptr416>3.0.co;2-r
Subject(s) - kampo , serotonin , antagonist , 5 ht receptor , stimulation , pharmacology , medicine , receptor antagonist , receptor , anesthesia , alternative medicine , pathology
In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose‐dependently improved by Choto‐san, but this effect was antagonized by NAN‐190, a serotonin 1A receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto‐san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did notinfluence the decreased serotonin concentration. These results suggested that Choto‐san showed theanti‐amnestic effect based on the stimulation of serotonin 1A receptors. Copyright © 1999 John Wiley & Sons, Ltd.