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Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from cachani complex plants upon the contractile activity of uterine smooth muscle
Author(s) -
PonceMonter Hector,
Campos Maria G.,
Aguilar Isabel,
Delgado Guillermo
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<202::aid-ptr418>3.0.co;2-r
Subject(s) - glycoside , propranolol , chemistry , uterine contraction , contraction (grammar) , cimetidine , calcium , stereochemistry , pharmacology , uterus , biochemistry , biology , endocrinology , organic chemistry
Xanthorrhizol, xanthorrhizol glycoside, and trachylobanoic acid, compounds isolated from medicinal plants that are grouped in the complex known as Cachani have been shown to inhibit the tonic contraction of rat uterus induced by: (a) depolarizing K + solution (60 m M ), (b) CaCl 2 (1 m M ), and (c) BAY K 8644 (0.3 µ M ) in a concentration‐dependent manner (1–30 µg/mL). The inhibitory potency was displayed as follows: xanthorrhizol > xanthorrhizol glycoside > trachylobanoic acid. These results suggest that the assayed compounds might block voltage operated calcium influx in myometrial cells as they displayed a calcium‐antagonistic activity. This effect is not due to peripheral receptor activation (β 2 ‐adrenergic, H 2 ‐histaminergic) as neither propranolol nor cimetidine modified the inhibitory effect of the compounds assayed. This is the first report showing that plants belonging to the Cachani complex may contain uterine smooth muscle bioactive substances. Copyright © 1999 John Wiley & Sons, Ltd.