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Anticancer potency of the milk extract of Semecarpus anacardium Linn. nuts against aflatoxin B 1 mediated hepatocellular carcinoma bearing wistar rats with reference to tumour marker enzymes
Author(s) -
Premalatha Balachandran,
Muthulakshmi Vallinayagam,
Sachdanandam Panchanatham
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199905)13:3<183::aid-ptr420>3.0.co;2-5
Subject(s) - aflatoxin , anacardium , hepatocellular carcinoma , lactate dehydrogenase , alkaline phosphatase , liver cancer , pharmacology , potency , carcinogen , traditional medicine , enzyme , biology , biochemistry , medicine , food science , in vitro , horticulture
Aflatoxin B 1 is an important consideration in the aetiology of human and animal hepatocellular carcinoma. The influence of the drug, Semecarpus anacardium Linn. nut extract, on hepatocarcinogenicity of aflatoxin B 1 was evaluated in adult albino male Wistar rats. Aflatoxin B 1 was administered intraperitoneally to induce hepatocellular carcinoma. These cancer bearing animals were treated with Semecarpus anacardium Linn. nut extract (200 mg/kg body weight/day) in sunflower oil orally for 14 days. The plasma and the liver tumour tissue were investigated biochemically for lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and γ‐glutamyl transpeptidase. The elevation of plasma concentration of these enzymes were indicative of the persistent deteriorating effect of aflatoxin B 1 in cancer bearing animals. Lactate dehydrogenase and aminotransferases levels were decreased in liver, whereas alkaline phosphatase and γ‐glutamyl transpeptidase were increased in cancer conditions. These enzyme levels were reversed to near normal control values in drug treated animals. The analysis of marker enzyme activities clearly indicates the antitumour efficacy of Semecarpus anacardium Linn. nut extract on aflatoxin B 1 induced hepatocellular carcinoma. Copyright © 1999 John Wiley & Sons, Ltd.