Premium
Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)
Author(s) -
Waechter AnneIsabelle,
Cavé André,
Hocquemiller Reynald,
Bories Christian,
Muñoz Victoria,
Fournet Alain
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199903)13:2<175::aid-ptr395>3.0.co;2-n
Subject(s) - annonaceae , antiprotozoal , aporphine , pharmacognosy , traditional medicine , alkaloid , chemistry , biology , stereochemistry , biological activity , medicine , biochemistry , in vitro
On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of Unonopsis buchtienii, the alkaloids and sterols isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against Leishmania major and L. donovani (IC 100 = 3.12 µg/mL). On the other hand, O ‐methylmoschatoline and the petroleum ether extract without alkaloids showed an interesting in vitro activity against Trypanosoma brucei with an IC 100 of 6.25 µg/mL. The highest cytotoxic activities were found with the petroleum ether extracts without alkaloids and with all alkaloids isolated (IC 50 < 9 µg/mL for Vero cell line). Copyright © 1999 John Wiley & Sons, Ltd.