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Microvascular protective activity of flavonoid glucuronides fraction from Tulipa gesneriana
Author(s) -
Budzianowsk Jaromir,
Korzeniowska Krystyna,
Chmara Ewa,
Mrozikiewicz Aleksander
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199903)13:2<166::aid-ptr407>3.0.co;2-l
Subject(s) - flavonoid , kaempferol , pharmacognosy , chemistry , quercetin , histamine , traditional medicine , vascular permeability , biological activity , pharmacology , biochemistry , biology , medicine , antioxidant , in vitro
A mixture of flavonoid glucuronides, consisting of 7‐O‐glucuronides of kaempferol and quercetin 3‐O‐rutinosides, 3‐O‐gentiobiosides and 3‐O‐glucosides, was isolated from the perianths of Tulipa gesneriana L. var. ‘ Paradae ’. It showed protective activity against the increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was 59.8% after peritoneal treatment at a dose of 25 mg/kg, while that of troxerutin was 45.5%. Copyright © 1999 John Wiley & Sons, Ltd.