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The effect of Maimendongtang on airway clearance and secretion
Author(s) -
Tai Shusheng,
Kai Hirofumi,
Isohama Yoichiro,
Moriuchi Hiroshi,
Hagino Nobuyoshi,
Miyata Takeshi
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199903)13:2<124::aid-ptr400>3.0.co;2-f
Subject(s) - secretion , airway , medicine , pharmacology , anesthesia
We investigated the effect of Maimendongtang on airway clearance and secretion in anaesthetized quails. The oral application of 1 g/kg of Maimendongtang significantly increased tracheal mucociliary transport velocity (MCTV), whereas 100 or 300 mg/kg of Maimendongtang failed to do so. Moreover, 300 mg/kg or 1 g/kg of Maimendongtang markedly attenuated human neutrophil elastase (HNE) or DNA‐induced decrease in MCTV although 100 mg/kg of Maimendongtang had little effect. Furthermore, we found that Maimendongtang significantly restored HNE‐induced increases in DNA, fucose and protein contents of airway surface fluid (ASF), whereas only Maimendongtang itself significantly decreased the protein content. These results indicate that Maimendongtang increases MCTV and the increase may be, at least in part, ascribed to the amelioration of ASF in the trachea. Copyright © 1999 John Wiley & Sons, Ltd.