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Prolonged murine genotoxic effects of crude extracted from neem
Author(s) -
Awasthy K. S.,
Chaurasia O. P.,
Sinha S. P.
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199902)13:1<81::aid-ptr385>3.0.co;2-w
Subject(s) - azadirachta , genotoxicity , metaphase , mitosis , biology , traditional medicine , ethanol , bone marrow , toxicology , chromosome , pharmacognosy , botany , chemistry , toxicity , biochemistry , genetics , immunology , medicine , in vitro , biological activity , organic chemistry , gene
Oral administration of a crude ethanol extract of the leaves of neem ( Azadirachta indica A juss) to adult Swiss albino mice for 7 days at 5 mg, 10 mg or 20 mg/10 g bw/day significantly increased the incidence of structural and mitosis disruptive changes in metaphase chromosomes of bone marrow cells on days 8, 15 and 35th of observation. It is proposed that one or other of the many constituents of the extract, along with genera free radicals, interfered with DNA to yield chromosome strand breakage or produced spindle disturbances, inducing belated genotoxic effects. Copyright © 1999 John Wiley & Sons, Ltd.