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Inhibitory effects of Sudanese plant extracts on HIV‐1 replication and HIV‐1 protease
Author(s) -
Hussein Ghazi,
Miyashiro Hirotsugu,
Nakamura Norio,
Hattori Masao,
Kawahata Takuya,
Otake Toru,
Kakiuchi Nobuko,
Shimotohno Kunitada
Publication year - 1999
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199902)13:1<31::aid-ptr381>3.0.co;2-c
Subject(s) - traditional medicine , bark (sound) , biology , inhibitory postsynaptic potential , hiv 1 protease , pharmacognosy , cytopathic effect , protease , virus , phytotherapy , virology , biological activity , in vitro , medicine , biochemistry , enzyme , ecology , neuroscience , alternative medicine , pathology
Forty‐eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV‐induced cytopathic effects (CPE) on MT‐4 cells. The extracts were further screened against HIV‐1 protease (PR) using an HPLC assay method. Of the tested extracts, the methanol extracts of Acacia nilotica (bark and pods), Euphorbia granulata (leaves), Maytenus senegalensis (stem‐bark) and aqueous extracts of A. nilotica (pods) and M. senegalensis (stem‐bark) showed considerable inhibitory effects against HIV‐1 PR. Inhibitory principles were isolated from M. senegalensis and their activities were also discussed. Copyright © 1999 John Wiley & Sons, Ltd.