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Some pharmacological effects of the ethanol extract of leaves of Annona diversifolia on the central nervous system in mice
Author(s) -
GonzálezTrujano M. E.,
Navarrete A.,
Reyes B.,
Hong E.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199812)12:8<600::aid-ptr363>3.0.co;2-n
Subject(s) - annonaceae , ethanol , pentobarbital , depressant , pharmacognosy , traditional medicine , central nervous system , pharmacology , annona , medicine , biology , toxicology , chemistry , biological activity , in vitro , biochemistry
In the present study we investigated some neuropharmacological effects of the ethanol extract of the leaves of Annona diversifolia (Annonaceae). Intraperitoneal administration of the extract delayed the onset of clonic seizures induced by pentylenetetrazole and delayed the time in the ‘rota‐rod’ and ‘swimming’ test. In addition, the extract augmented the duration of sleeping time induced by sodium pentobarbital. These results indicate that the ethanol extract of the leaves of A. diversifolia has depressant activity on the central nervous system. Copyright © 1998 John Wiley & Sons, Ltd.