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In vitro antiviral effects of an aqueous extract of Artemisia verlotorum Lamotte (Asteraceae)
Author(s) -
Calderone Vincenzo,
Nicoletti Elisa,
Bandecchi Patrizia,
Pistello Mauro,
Mazzetti Paola,
Martinotti Enrica,
Morelli Ivano
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199812)12:8<595::aid-ptr352>3.0.co;2-6
Subject(s) - in vitro , virus , virology , biology , capsid , feline immunodeficiency virus , chemistry , biochemistry , lentivirus , viral disease
Plants represent a possible source of new interesting antiviral drugs. An aqueous extract of Artemisia verlotorum exhibited, in vitro , strong activity against the feline immunodeficiency virus (FIV), which can be considered a reliable model of the human immunodeficiency virus type 1, the aetiological agent of AIDS. The extract determined a decrease of the virus‐induced syncytia in the cultured cells, an inhibition of the viral reverse transcriptase activity and a reduction of the viral capsid protein P24 expression. Copyright © 1998 John Wiley & Sons, Ltd.