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Experimental evaluation of Myracrodruon urundeuva bark extract for antidiarrhoeal activity
Author(s) -
Chaves M. C.,
Santos F. A.,
Menezes A. M. S.,
Rao V. S. N.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199812)12:8<549::aid-ptr357>3.0.co;2-l
Subject(s) - antidiarrhoeal , bark (sound) , traditional medicine , castor oil , intestinal motility , anacardiaceae , pharmacognosy , apocynaceae , histamine , motility , acetylcholine , in vitro , pharmacology , biology , medicine , botany , biological activity , biochemistry , ecology , genetics
The bark of M. urundeuva (Anacardiaceae) used in popular medicine as an antidiarrhoeal agent has been investigated for its effects on castor oil‐induced diarrhoea and on intestinal motility. In rats, the ethanol extract of stem bark significantly inhibited the castor oil‐induced diarrhoea, small intestinal transit and accumulation of fluid volume at an oral dose of 400 mg/kg. Furthermore, the plant extract caused marked inhibition of the contractile responses evoked by acetylcholine and histamine on guinea‐pig ileum in vitro. These results point to a possible antidiarrhoeic effect of M. urundeuva bark extract since inhibition of intestinal motility and secretion can greatly control clinical diarrhoea. Copyright © 1998 John Wiley & Sons, Ltd.