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Leishmanicidal and Trypanocidal activities of Acetogenins isolated from Annona glauca
Author(s) -
Waechter AnneIsabelle,
Yaluff Gloria,
Inchausti Alba,
de Arias Antonieta Rojas,
Hocquemiller Reynald,
Cavé André,
Fournet Alain
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199812)12:8<541::aid-ptr358>3.0.co;2-5
Subject(s) - trypanosoma cruzi , annonaceae , leishmania , biology , antiprotozoal , kinetoplastida , pharmacognosy , traditional medicine , trypanosoma , leishmaniasis , leishmania major , leishmania donovani , in vitro , microbiology and biotechnology , botany , biological activity , parasite hosting , virology , visceral leishmaniasis , medicine , biochemistry , immunology , world wide web , computer science
The dichloromethane extract of seeds of Annona glauca (Annonaceae) was active against three strains of Leishmania species. Nine known acetogenins were isolated and identified and then evaluated in vitro against Leishmania species and the bloodstream forms of Trypanosoma cruzi. Annonacin A and goniothalamicin showed activity against Leishmania, and glaucanisin, squamocin, annonacin A and annonacin against Trypanosoma cruzi reducing the parasites by 78%, 67%, 71% and 85%, respectively. Copyright © 1998 John Wiley & Sons, Ltd.