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Inhibition of leukotriene biosynthesis and lipid peroxidation in biological models by the extract of Cassia fistula
Author(s) -
K. C. Sunil Kumar,
Müller Klaus
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199811)12:7<526::aid-ptr346>3.0.co;2-3
Subject(s) - lipid peroxidation , cassia , lipoxygenase , liposome , chemistry , ic50 , phospholipid , enzyme , biochemistry , biosynthesis , leukotriene , arachidonate 5 lipoxygenase , antioxidant , pharmacology , in vitro , biology , medicine , arachidonic acid , membrane , immunology , alternative medicine , traditional chinese medicine , pathology , asthma
The methanol extract obtained from the fruits of Cassia fistula L. inhibited the 5‐lipoxygenase catalysed formation of leukotriene B 4 in bovine polymorphonuclear leukocytes with an IC 50 value of 38 μg/mL. Also, lipid peroxidation in bovine brain phospholipid liposomes induced with 2,2′‐azo‐bis‐(2‐amidinopropane) dihydrochloride (AAPH) was inhibited with an IC 50 value of 40 μg/mL. A linear correlation was obtained between the effects of the extract in the two kinds of assays suggesting a redox‐based mechanism for the inhibition of the 5‐lipoxygenase enzyme. Copyright © 1998 John Wiley & Sons, Ltd.