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Influence of dihydroquercetin on the lipid peroxidation of mice during post‐radiation period
Author(s) -
Teselkin Yu. O.,
Babenkova I. V.,
Tjukavki. A.,
Rulenko I. A.,
Kolesnik Yu. A.,
Kolhir V. K.,
Eichholz A. A.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199811)12:7<517::aid-ptr342>3.0.co;2-d
Subject(s) - lipid peroxidation , antioxidant , thiobarbituric acid , chemiluminescence , chemistry , irradiation , biochemistry , medicine , chromatography , nuclear physics , physics
The effect of the natural antioxidant dihydroquercetin was examined on the process of free radical oxidation of serum and liver lipids of mice, after a single 4 Gy dose of γ‐irradiation. The content of lipid peroxidation products reacting with thiobarbituric acid in irradiated animals receiving oral dihydroquercetin (experimental) for 155 days after irradiation was significantly lower compared with animals receiving irradiation and no antioxidant (controls). The intensity of Fe 2+ ‐induced chemiluminescence of liver homogenates of experimental mice was lower by the end of the experiment ( p < 0.001) than the chemiluminescence of liver homogenates of both control and intact animals. It is assumed that this was due to the preferential uptake of dihydroquercetin by the liver. Copyright © 1998 John Wiley & Sons, Ltd.