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Acute preclinical toxicity study of Zanthoxylum naranjillo extract
Author(s) -
Rodrigues Élcio R.,
Pedrazzi Antenor H. P.,
Bastos Jairo K.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199811)12:7<512::aid-ptr369>3.0.co;2-5
Subject(s) - toxicity , pharmacology , albumin , alkaline phosphatase , medicine , acute toxicity , analgesic , median lethal dose , bone marrow , traditional medicine , chemistry , biochemistry , enzyme
In previous studies, Zanthoxylum naranjillo hexane crude extract revealed marked analgesic and antimalarial activities. This paper reports an investigation of preclinical toxicity in acute phase ( 24 h and 15 days with repeated doses ) in which the action of different extract doses ( 15, 150 and 450 mg/kg ) was evaluated. Wistar rats weighing 300 ± 15 g were submitted to toxicological evaluation of clinical chemical, haematological and haemostatic blood parameters including evaluation of liver, pancreas, kidneys, bile ducts, heart, serum lipids, bonc marrow, haematological and haemostatic systems. The initial results showed an alteration of albumin and alkaline phosphatase at some of the doses tested, but without suggesting hepatic or biliary involvement. Copyright © 1998 John Wiley & Sons, Ltd.