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Antiperoxidative effect of Livex, a herbal formulation against erythromycin estolate induced lipid peroxidation in rats
Author(s) -
Venkateswaran S.,
Pari L.,
Viswanathan P.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199811)12:7<465::aid-ptr318>3.0.co;2-2
Subject(s) - lipid peroxidation , pharmacology , erythromycin , antioxidant , chemistry , biochemistry , medicine , antibiotics
The present study was carried out to investigate the antiperoxidative effect of Livex, a compound herbal formulation, against erythromycin estolate induced lipid peroxidation. The oral administration of Livex to rats along with erythromycin estolate caused a significant reversal in lipid peroxidation, enzymatic leakage and produced enhancement of cellular antioxidant defence, revealing that the antioxidative action of Livex is responsible for its protective activity. These observations were supplemented by histopathological examination of liver and kidney sections. The results of this study revealed that Livex could afford significant protection against erythromycin estolate induced lipid peroxidation. Copyright © 1998 John Wiley & Sons, Ltd.