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Rubia cordifolia extract inhibits cell proliferation in A‐431 cells
Author(s) -
Tripathi Yamini B.,
Shukla Shivendra D.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199809)12:6<454::aid-ptr331>3.0.co;2-n
Subject(s) - dna synthesis , cell growth , thymidine , cell culture , tetradecanoylphorbol acetate , biology , fibroblast , rubiaceae , phorbol , cell , chemistry , fetal bovine serum , microbiology and biotechnology , biochemistry , dna , in vitro , botany , signal transduction , genetics , protein kinase c
The antiproliferative property of Rubia cordifolia (Rubiaceae) extract has been studied on two different cell types, A‐431 cells (epidermal carcinomoid cells) and 3T3 fibroblast cells. It was observed that a fraction of Rubia cordifolia significantly inhibited the incorporation of [ 3 H]‐thymidine, induced by fetal bovine serum, in a dose‐dependent manner. It also inhibited the PMA (phorbol 12‐myristate 13‐acetate) induced expression of c‐fos genes in A‐431 cells. It appears that inhibition of DNA synthesis underlies the mechanism for its antiproliferative properties. © 1998 John Wiley & Sons, Ltd.