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The topical antiinflammatory effect of chloroform extract from Khaya senegalensis stem barks
Author(s) -
Lompo M.,
Nikiéma J. B.,
Guissou I. P.,
Moës A. J.,
Fontaine J.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199809)12:6<448::aid-ptr325>3.0.co;2-1
Subject(s) - khaya , petroleum ether , chloroform , traditional medicine , croton , croton oil , pharmacognosy , chemistry , meliaceae , pharmacology , medicine , biological activity , chromatography , biochemistry , in vitro , extraction (chemistry) , inflammation
The croton oil‐induced mice ear oedema test was used to study the topical antiinflammatory effects of petroleum ether and chloroform extracts of Khaya senegalensis stem barks. It was found that these fractions exhibited dose‐dependent inhibitory effects. The chloroform extract activity was closely related to that of indomethacin used as standard, was more active than the petroleum ether extract and played a pivotal role in the topical antiinflammatory effect of Khaya senegalensis stem barks. © 1998 John Wiley & Sons, Ltd.