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Biologically active flavonoids and kava pyrones from the aqueous extract of Alpinia zerumbet
Author(s) -
Mpalantinos M. A.,
Soares de Moura R.,
Parente J. P.,
Kuster R. M.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199809)12:6<442::aid-ptr320>3.0.co;2-y
Subject(s) - rutin , chemistry , traditional medicine , kaempferol , pharmacognosy , alpinia , zingiberaceae , flavonoid , stereochemistry , biological activity , organic chemistry , biochemistry , rhizome , medicine , antioxidant , in vitro
From the aqueous extract of Alpinia zerumbet (Pers) B. L. Burttet Smith. (= Alpinia speciosa K. Schum.) flavonoids and kava pyrones were obtained. The flavonoids identified as rutin (1), kaempferol‐3‐ O ‐rutinoside (2), kaempferol‐3‐ O ‐glucuronide (3), (+)‐catechin (4) and (−)‐epicatechin (5) are well known substances that can contribute to the hypotensive, diuretic and antiulcerogenic activity of the aqueous extract of the plant, while the kava pyrones dihydro‐5,6‐dehydrokawain (6) and 5,6‐dehydrokawain (7) have been described as antiulcerogenic and antithrombotic. The compounds were identified from their UV, 1 H‐ and/or 13 C‐NMR, hydrolytic and co‐TLC data. The well known activity of these compounds, which have not been previously isolated from the leaves of Alpinia zerumbet, may explain the use of the plant in the treatment of hypertension. © 1998 John Wiley & Sons, Ltd.