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Effects of crinum glaucum aqueous extract on intestinal smooth muscle activity
Author(s) -
Okpo S. O.,
Adeyemi O. O.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199809)12:6<413::aid-ptr326>3.0.co;2-g
Subject(s) - taenia coli , acetylcholine , histamine , ileum , guinea pig , smooth muscle , calcium , chemistry , potassium , aqueous extract , pharmacology , endocrinology , medicine , biology , biochemistry , traditional medicine , organic chemistry
Crinum glaucum aqueous extract (1–8 mg/mL) produced a concentration dependent, non‐competitive inhibition of contractions induced by acetylcholine (1.1 × 10 −8 –3.3 × 10 −7 M ) and calcium chloride (CaCl 2 , 0.05–2 m M ) on the rat duodenum. Contractions of the guinea‐pig ileum induced by acetylcholine (1.1 × 10 −8 –3.3 × 10 −7 M ) and histamine (1.1 × 10 −8 –3.3 × 10 −7 M ) were inhibited by the extract (1–4 mg/mL). The extract (0.125–2.0 mg/mL) also, produced a concentration dependent relaxation of the guinea‐pig taenia coli, precontracted with potassium chloride (40 m M ). It is concluded that the extract is a non‐specific relaxant of the gastrointestinal smooth muscles used. © 1998 John Wiley & Sons, Ltd.