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The inhibitory effects of ginsenoside and quercetin on oxidative damage by puromycin aminonucleoside in rat
Author(s) -
Lim Beong Ou,
Yu Byung Pal,
Oh JunHawn,
Park Dong Ki
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199808)12:5<375::aid-ptr315>3.0.co;2-f
Subject(s) - quercetin , nephrosis , antioxidant , chemistry , puromycin , pharmacology , glutathione peroxidase , oxidative stress , glutathione , biochemistry , medicine , biology , enzyme , catalase , protein biosynthesis
This study examined the protective effect of two natural antioxidants, ginsenoside Rb‐1 and quercetin, on acute nephrosis induced by puromycin aminonucleoside (PA). The protective action of Rb‐1 and quercetin were evidenced by their ability to suppress the formation of phosphatidylcholine hydroperoxide in the plasma, liver and kidney. Another beneficial effect noted from these natural antioxidants was increased glutathione peroxidase activity in the blood. Our results suggest that the severity of PA‐induced acute nephrosis can be ameliorated by the antioxidative action of these two flavonoids. © 1998 John Wiley & Sons, Ltd.