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Antiviral activity in vitro of Cupressus sempervirens on two human retroviruses HIV and HTLV
Author(s) -
Amouroux Pierre,
Jean Daniel,
Lamaison JeanLouis
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199808)12:5<367::aid-ptr301>3.0.co;2-n
Subject(s) - in vitro , cupressaceae , biology , virology , human immunodeficiency virus (hiv) , pharmacognosy , traditional medicine , botany , biological activity , medicine , biochemistry , pollen
A proanthocyanidin polymer fraction (MW 1500–2000 daltons) from Cupressus sempervirens L. (Cupressaceae) exhibited true antiviral activity in vitro against two retroviruses, HIV and HTLV III B. In comparison with AZT no toxicity was observed with PPC at concentrations of 50 μg/mL which exceeded the IC 50 values (1.5 to 15 μg/mL for HIV and 5 to 25 μg/mL for HTLV). © 1998 John Wiley & Sons, Ltd.