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Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats
Author(s) -
Yagi S. M.,
Tigani S. El,
Adam S. E. I.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199808)12:5<324::aid-ptr300>3.0.co;2-2
Subject(s) - emodin , anthraquinones , kaempferol , traditional medicine , fermentation , senna , biology , toxicity , botany , chemistry , food science , flavonoid , biochemistry , medicine , antioxidant , organic chemistry
The present study investigated the effects induced on albino rats by Senna obtusifolia fresh leaves and fermented (kawal) leaves, S. alata leaves, as well as the ethanol extract and pure compounds, namely, emodin, kaempferol, aloe‐emodin, and rhein from the latter species. The present results indicate that the leaves of both S. obtusifolia and S. alata can cause marked toxic effects on rats, and that the processing of the leaves of the former species by fermentation to produce kawal did not alter the toxic activity of the ingredients in the leaves. Also the ethanol extract and compounds isolated from S. alata can cause subtle hepatorenal toxicity. Moreover, the present study suggests that anthraquinones have a mechanism of synergistic action when used collectively as present in the leaves. © 1998 John Wiley & Sons, Ltd.