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In vivo effects of Aloe arborescens Miller var. natalensis Berger ( Kidachi aloe ) on experimental tinea pedis in guinea‐pig feet
Author(s) -
Kawai K.,
Beppu H.,
Shimpo K.,
Chihara T.,
Yamamoto N.,
Nagatsu T.,
Ueda H.,
Yamada Y.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199805)12:3<178::aid-ptr218>3.0.co;2-f
Subject(s) - trichophyton , guinea pig , traditional medicine , antifungal , biology , in vivo , in vitro , inoculation , pharmacognosy , botany , microbiology and biotechnology , medicine , horticulture , biological activity , biochemistry , endocrinology
Trichophytosis was induced in guinea‐pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger ( Kidachi aloe ) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM‐110 ( T. mentagrophytes SM‐110) onto the plantar part of guinea‐pig feet. Culture studies after application of 30% freeze‐dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10 000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL. © 1998 John Wiley & Sons, Ltd.