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Antiinflammatory activity of binaphthaquinones from Diospyros species
Author(s) -
Kuke Constanze,
Williamson Elizabeth M.,
Roberts Margaret F.,
Watt Robert,
Hazra Banasri,
Lajubutu Bolanle A.,
Yang ShiLin
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199805)12:3<155::aid-ptr214>3.0.co;2-1
Subject(s) - plumbagin , mechanism of action , cytotoxicity , biological activity , chemistry , pharmacology , enzyme , enzyme assay , platelet aggregation , pharmacognosy , structure–activity relationship , stereochemistry , biochemistry , in vitro , platelet , medicine , biology , immunology , botany
The antiinflammatory activity of five structurally related binaphthaquinones and plumbagin has been studied using a blood platelet aggregation assay. The results suggest that for maximum activity a free hydroxyl peri to the quinoid ring is important. Antiplatelet activity does not correlate with other previously determined biological activity, such as antitumour action, but is consistent with the theory of free radical generation as a mechanism for cytotoxicity and enzyme inhibition but not antiinflammatory activity. © 1998 John Wiley & Sons, Ltd.