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Effects of Panax notoginseng saponins on platelet aggregation in rats with middle cerebral artery occlusion or in vitro and on lipid fluidity of platelet membrane
Author(s) -
Ma L. Y.,
Xiao P. G.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199803)12:2<138::aid-ptr200>3.0.co;2-c
Subject(s) - panax notoginseng , platelet , membrane fluidity , in vivo , in vitro , chemistry , pharmacology , platelet adhesiveness , platelet aggregation , platelet activation , membrane , medicine , biochemistry , biophysics , biology , pathology , microbiology and biotechnology , alternative medicine
The effects were examined of Panax notoginseng saponins (PNS) on platelet aggregation in vivo or in vitro and on lipid fluidity of the membrane. PNS (200 mg/kg i.p. ×1 d or ×3 d) significantly inhibited abnormal increases of platelet aggregation and platelet adhesiveness in rats subjected to permanent occlusion of the middle cerebral artery (MCAO). Platelet aggregation induced by ADP in vitro was also inhibited by PNS in a concentration‐related manner. PNS could increase the fluidity of platelet membranes. The findings in this study suggest that the anticerebral ischaemic effect of PNS depends, at least partially, for its actions on blood platelets. © 1998 John Wiley & Sons, Ltd.