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Effect of tea root extract (TRE) on solid tumours induced by 3‐methylcholanthrene in mice
Author(s) -
Chaudhuri T.,
Sur P.,
Gomes A.,
Das S. K.,
Das M.,
Ganguly D. K.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<62::aid-ptr184>3.0.co;2-4
Subject(s) - tbars , thiobarbituric acid , methylcholanthrene , superoxide dismutase , chemistry , scavenger , traditional medicine , pharmacology , antioxidant , biology , biochemistry , medicine , lipid peroxidation , carcinogen
The antitumour effect of tea plant root extract (TRE) has been evaluated against a 3‐methylcholanthrene (3‐MC) induced solid tumour model in ICR mice. TRE inhibited the tumur weight and the tumours were found to be non‐necrotic. Superoxide dismutase (SOD), a free radical scavenger, in the sera of TRE treated tumour bearing mice was found to be significantly increased while the SOD level in untreated tumour bearing animals was low. Moreover, the enhanced level of thiobarbituric acid reactive substance (TBARS) in sera of tumour bearing mice were normalized upon TRE treatment. © 1998 John Wiley & Sons, Ltd.