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Inhibitory effects of isoflavones in roots of Astragalus membranaceus BUNGE (Astragali Radix) on lipid peroxidation by reactive oxygen species
Author(s) -
Toda Shizuo,
Shirataki Yoshiaki
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<59::aid-ptr182>3.0.co;2-r
Subject(s) - formononetin , lipid peroxidation , calycosin , isoflavones , chemistry , reactive oxygen species , antioxidant , superoxide , xanthine oxidase , biochemistry , hydrogen peroxide , traditional medicine , pharmacology , biology , daidzein , medicine , genistein , enzyme , endocrinology
Possible inhibitory effects were investigated of isoflavones in the roots of Astragalus membranaceus BUNGE (Astragali Radix), afrormosin, calycosin, formononetin and odoratin on lipid peroxidation by reactive oxygen species. Calycosin inhibited lecithin peroxidation which was induced by hydroxy radical‐generation by interaction of haemoglobin and hydrogen peroxide. Calycosin and formononetin inhibited lecithin peroxidation which was induced by superoxide anion generation by xanthine‐xanthine oxidase. Other isoflavones had no inhibitory effects on lecithin peroxidations. These results demonstrated that the antioxidant properties of isoflavones, which have a methoxy group at the 4′ position, are derived from hydroxy groups at the 7 and 4′ position. © 1998 John Wiley & Sons, Ltd.