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Protective role of curcumin in ethanol toxicity
Author(s) -
Rajakrishnan V.,
Me Venugopal P.,
Rajashekaran K. N.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<55::aid-ptr173>3.0.co;2-0
Subject(s) - curcumin , toxicity , ethanol , chemistry , alkaline phosphatase , thiobarbituric acid , pharmacology , aspartate transaminase , acute toxicity , biochemistry , alanine transaminase , lipid peroxidation , medicine , endocrinology , enzyme , organic chemistry
The effect of curcumin on ethanol induced liver toxicity was evaluated. The increased levels of aspartate transaminase and alkaline phosphatase induced by ethanol were significantly lowered by curcumin. Elevated serum cholesterol, phospholipids and free fatty acids were observed in ethanol fed rats, but on curcumin treatment they decreased. We have also observed a marked decrease in the levels of thiobarbituric acid reactive substances in serum of alcoholic rats fed curcumin. Thus this study shows that curcumin offers protection against ethanol induced toxicity. © 1998 John Wiley & Sons, Ltd.