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Effects of aqueous extracts of Apocynum venetum leaves on hypercholesterolaemic rats
Author(s) -
Kim DongWook,
Yokozawa Takako,
Hattori Masao,
Kadota Shigetoshi,
Namba Tsuneo
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<46::aid-ptr169>3.0.co;2-i
Subject(s) - cholesterol , total cholesterol , serum cholesterol , aqueous extract , ldl cholesterol , chemistry , medicine , endocrinology , traditional medicine , biology
The extracts of dried leaves of Apocynum venetum collected in different places in China (Luobuma I and II), and two processed leaves (Luobuma III and IV), were investigated on serum lipid and hepatic total cholesterol levels in cholesterol‐fed rats. The serum total cholesterol levels were significantly reduced on day 40 in rats given the roasted leaf extracts (Luobuma III and IV) with p <0.05 and p <0.01, respectively, when compared with a control value of cholesterol‐fed rats. In the serum lipoproteins, the LDL‐cholesterol levels were significantly lower in rats given each sample extract on day 40, compared with the control value, and the HDL‐cholesterol levels were significantly higher than that of a control group, except for a group given Luobuma I. Furthermore, the respective atherogenic indices were significantly lower in all groups given Luobuma I to IV, compared with the control value. The hepatic total cholesterol levels were also significantly lower in all of the groups given the Luobuma extracts than that of control rats on day 40. These results suggest that the extract of A. venetum leaves is effective for hypercholesteraemia and the prevention of atherosclerosis. © 1998 John Wiley & Sons, Ltd.