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Antipyretic effect of Azadirachta indica in bacteria endotoxin induced fever in the rat
Author(s) -
Ashorobi R. B.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<41::aid-ptr108>3.0.co;2-5
Subject(s) - azadirachta , antipyretic , rectal temperature , traditional medicine , bacteria , phytotherapy , medicine , biology , chemistry , pharmacology , anesthesia , analgesic , pathology , genetics , alternative medicine
Fever was induced in rats with a single i.p. injection of 30 μg/kg E. coli endotoxin. The effect of the alcohol leaf extract of Azadirachta indica was investigated in this model. Pretreatment of rats with the leaf extract (125–375 mg/kg) did not significantly reduce endotoxin‐induced fever. The rectal temperature remained significantly high. In contrast, administration of the same doses of the extract during the early phase of fever development (during temperature rise) produced a significant fall in the rectal temperature to near normal. The maximum rise was 1.0°C which later dropped to 0.18°C, and was sustained even beyond the experimental session. The data obtained suggest the beneficial antipyretic effect of the leaf extract of Azadirachta indica in bacteria endotoxin induced fever. © 1998 John Wiley & Sons, Ltd.