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Andrographolide inhibits the tumour necrosis factor‐α‐induced upregulation of ICAM‐1 expression and endothelial‐monocyte adhesion
Author(s) -
Habtemariam Solomon
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<37::aid-ptr186>3.0.co;2-n
Subject(s) - andrographolide , andrographis paniculata , monocyte , intercellular adhesion molecule 1 , tumor necrosis factor alpha , cell adhesion molecule , adhesion , downregulation and upregulation , icam 1 , cell adhesion , pharmacology , e selectin , chemistry , biochemistry , immunology , biology , medicine , pathology , alternative medicine , organic chemistry , gene
Andrographolide, a diterpene isolated from Andrographis paniculata , has been shown to have several biological activities including analgesic, antipyretic and antiinflammatory effects. Since the upregulation of adhesion molecules expression and endothelial‐leucocytes adhesion are key steps in the development of inflammation, the present study examines whether andrographolide modulates these biological processes in vitro . Incubation of endothelial cells with non‐toxic concentrations (0.16–16.7 υg/mL) of andrographolide attenuated the tumour necrosis factor‐α (TNF)‐induced intercellular adhesion molecule‐1 (ICAM‐1) expression. Similar concentration ranges of andrographolide also inhibited the TNF‐induced endothelial‐monocyte adhesion in a concentration‐dependent manner. These effects of andrographolide may account for its reported in vivo antiinflammatory activity. © 1998 John Wiley & Sons, Ltd.