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Gastroprotective activity of the stem bark of Amphipterygium adstringens in rats
Author(s) -
Navarrete A.,
MartínezUribe L. S.,
Reyes B.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(19980201)12:1<1::aid-ptr177>3.0.co;2-h
Subject(s) - traditional medicine , pharmacognosy , positive control , bark (sound) , fractionation , ethanol , chemistry , phytotherapy , pharmacology , medicine , biological activity , biology , in vitro , chromatography , biochemistry , alternative medicine , pathology , ecology
The methanol extract of the stem bark of Amphipterygium adstringens (Julianiaceae) showed a dose‐dependent inhibitory effect on ethanol‐induced gastric ulcers in rats. Fractionation of this extract, guided by gastroprotective activity in rats, led to four active fractions rich in triterpenoid compounds. These fractions showed higher antiulcer activity than bismuth subsalicylate, used as a positive control. 3α‐Hydroxy‐ masticadienonic acid was isolated from the active fractions, however, this compound showed lower antiulcer activity than the positive control. © 1998 John Wiley & Sons, Ltd.