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Sedative and spasmolytic effects of Viburnum tinus L. and its major pure compounds
Author(s) -
Cometa M. F.,
Mazzanti G.,
Tomassini L.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(1998)12:1+<s89::aid-ptr260>3.0.co;2-t
Subject(s) - sedative , viburnum , traditional medicine , caprifoliaceae , pharmacognosy , pharmacology , medicine , chemistry , biological activity , biology , botany , in vitro , biochemistry
Viburnum species are used in folk medicine because of their diuretic, antispasmodic and sedative properties. In this study the sedative and antispasmodic activities of a total extract from Viburnum tinus and its major compounds (viburtinoside I, II/III) were evaluated on spontaneous locomotor activity in mice and on isolated rabbit jejunum. V. tinus and its components reduced spontaneous activity in mice, viburtinoside I being more potent than viburtinoside II/III. The isolated compounds also had spasmolytic action in vitro , viburtinosides II/III being more potent than viburtinoside I. © 1998 John Wiley & Sons, Ltd.